Are you ready for some cold beers and great company in the summer? Boston QSP is excited to announce our upcoming July event in the Modeling & Simulation in Drug Development series, on July 17th. This event will feature a talk by our speaker Suzanne Gaudet, a Assistant Professor from Dept. of Cancer Biology, Dana-Farber Cancer Institute, and from Dept. of Genetics, Blavatnik Institute, Harvard Medical School. The talk will be followed by a mixer and reception where you can enjoy great company and conversation with fellow community members over chill craft beers and delicious pizza from a local small business.
The event is sponsored by Applied BioMath. The venue is sponsored by CIC.
5:00-5:30 PM: Registration (outside Havana Room)
5:30-6:20 PM: Presentation and Q&A. Presentation title: “Transcriptional dynamics as a driver of phenotypic diversity” (Havana Room)
6:20-7:30 PM: Mixer & Reception (Venture Café, a few steps down the hallway from the
Venue: Cambridge Innovation Center, 1 Broadway, Cambridge.
RSVP here Limited seats. * Please do not hesitate to RSVP on the waiting list if the RSVP is full as some guests "un-RSVP" as the event gets closer.
In the last 10 years, Suzanne Gaudet has run a research group at the Department of Cancer Biology and the Center for Cancer Systems Biology at the Dana-Farber Cancer Institute and the Department Genetics at Harvard Medical School. Her research has focused on the quantitative understanding of how cells, in particular cancer cells, dynamically respond to cytokine signals from the immune system. She received a B.Sc. in Biology from Université de Montréal and earned a Ph.D. in Biochemistry from Harvard University working with Daniel Branton. She then joined Peter Sorger’s laboratory at MIT as a postdoctoral associate for the launch of an
interdisciplinary research collaborative at the interface of biology, informatics and microdevice engineering. From 2003 to 2008, she worked as a research scientist and scientific coordinator at the Cell Decision Processes Center at MIT and Harvard, taking pride in seeding multiple collaborations between scientists and engineers. She is committed to promoting diversity in science through better mentorship and leadership.
Cytokines can activate complex signaling networks to induce a variety of cellular behaviors including survival, proliferation, differentiation and cell death. For example, even within a clonal population of cells, the response to TNF is often striking heterogeneous, and this is reflected in the cell-to-cell variability in TNF-induced transcriptional responses driven by the NF-κB transcription factor. In our work, we combine single-cell measurements of NF-κB activation dynamics and transcript numbers with computational models to better understand how cells dynamically integrate information and to investigate the sources of cell-to-cell variation that ultimately shape a cell’s response to TNF. I will discuss our recent work, showing how NF-κB transcription factor and chromatin together modulate expression noise patterns of both endogenous genes and latent HIV to drive phenotypic diversity.
About Boston QSP
Boston QSP is a 501(c)(3) non-profit organization whose mission is to foster the sharing of QSP knowledge, challenges, solutions, and opportunities to advance the field as an interdisciplinary community in Boston.